Levosulpiride-induced Parkinsonism is the development of Parkinsonism symptoms as a side-effect of taking levosulpiride, an antipsychotic and prokinetic agent.
Levosulpiride is primarily used to treat dyspepsia, irritable bowel syndrome, and symptoms of gastroparesis. It is sometimes prescribed for depression and anxiety also.
Levosulpiride works by blocking dopamine receptors in the brain, which can alleviate symptoms of conditions like schizophrenia and gastrointestinal disorders.
As dopamine is a crucial neurotransmitter for motor control, by inhibiting its pathways, it can inadvertently lead to the symptoms of drug-induced Parkinsons.
Levosulpiride-induced Parkinsonism is a potentially reversible condition, provided that it is identified early and managed appropriately by adjusting or discontinuing the medication.
Levosulpiride use can result in Parkinsonism and other movement disorders. It should be avoided, especially in the elderly population,” added Dr Sudhir Kumar.