Persisting fatigue after Covid-19: Scientists now know the reason

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By Sumit Jha

08/01/2024

Recent scientific discoveries have shed light on the root cause of the enduring fatigue experienced by individuals with long-Covid or post-Covid conditions.

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Researchers have identified a biological factor contributing to persistent exhaustion: A decrease in energy production within the mitochondria of muscle cells.

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Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) offered insight into the issue in a study published in the journal Nature Communications.

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As many as 25 people diagnosed with long Covid and 21 healthy control participants took part in a cycling test lasting 15 minutes for the study.

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Results revealed that the cycling test induced a prolonged exacerbation of symptoms in the long-Covid patients, a phenomenon known as post-exertional malaise (PEM).

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“In concrete terms, we advise these patients to guard their physical limits and not to exceed them.” said Brent Appelman a researcher at Amsterdam UMC.

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“Most long Covid patients either get on with their life with the impairment. They don’t enter any records or journal publications. Many people suffer in silence,” shares Dr Jayadevan.

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“With no specific cure in sight, WHO says the only method to avoid long Covid is to not get Covid. Hence the value for specific mitigation measures,” he said.

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