Kerala sets benchmark, releases guidelines for managing Amoebic Meningoencephalitis

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By Sreelakshmi Soman

Jul 22, 2024

Kerala released comprehensive “Technical Guidelines on Prevention, Diagnosis, and Treatment of Amoebic Meningoencephalitis”.

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The rare brain infection is caused by a free-living amoeba found in contaminated waters.

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Any patient presenting with the symptoms of acute meningitis should be asked about nasal exposure to fresh water in the past 14 days. 

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For patients with a recent history of nasal exposure to fresh water, Cerebrospinal Fluid (CSF) specimen should be rapidly tested for N. fowleri/FLA.

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In cases where bacterial meningitis patients do not respond to antibiotics or deteriorate rapidly, Primary Amoebic Meningoencephalitis (PAM) should be considered.

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Wet mount examination of all turbid or opalescent CSF samples is mandatory as it helps in the early detection of PAM.

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Confirmed PAM cases must be reported to the District Surveillance Officer (DSO), with CSF samples sent for PCR and genome sequencing if necessary. 

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Treatment of PAM should involve a multi-disciplinary team, including Physicians, Pediatricians, Intensivists, Infectious Disease Specialists, Neurologists, and Microbiologists. 

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