HER2-positive breast cancer, and a ₹4.2 lakh free treatment initiative

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By Sumit Jha

Feb 06, 2024

In a groundbreaking move, Goa has emerged as the first state in the nation to offer the Pertuzumab-Trastuzumab combination to breast cancer patients in hospitals completely free.

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Pertuzumab-trastuzumab (Phesgo), a potent fixed drug combination designed for HER2-positive breast cancer. In India, a single dose of Phesgo costs approximately ₹2.1 lakh.

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HER2-positive breast cancer denotes a subtype characterised by the overexpression or amplification of a protein known as HER2 (human epidermal growth factor receptor 2).

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The steep cost of medications like Pertuzumab and Trastuzumab can be attributed to extensive research and development (R&D) expenses.

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Biologic drugs, such as monoclonal antibodies like Phesgo, are more complex to manufacture than traditional chemical-based drugs, adding to production expenses.

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Dr Dr Nitin Yashas, a Hemato-Oncologist highlighted, “By the addition of Pertuzumab, we are able to achieve a dual HER2 blockade leading to better response and better survival.”

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“When we give this combination along with chemotherapy for typically six cycles before surgery and then operate, there is excellent reduction of the tumour.”

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“In 60-70 percent of the cases, the final pathology reports show no evidence of cancer cells,” he adds.

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