DENV-3 variant of dengue dominates Bengaluru: How effective will the vaccine be?

Health By Sumit Jha Sep 17, 2024 Read the article

Dengue is evolving, and the vaccine intended for people in India is still under development.

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As of 16 September, Karnataka has reported 27,351 dengue cases in 2024 with 12 deaths.

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Bengaluru leads with a whopping 12,594 cases, highlighting the city’s growing dengue crisis and the associated vaccine challenge.

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A recent article in The Lancet highlights a significant rise in the dominance of dengue virus serotype 3 (DENV-3).

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This shift poses critical implications for vaccine efficacy, as current dengue vaccines have shown limited effectiveness against DENV-3 in clinical trials.

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The study emphasises the importance of region-specific serotype understanding, which is essential as India moves toward phase 3 trials of quadrivalent dengue vaccines.

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The authors emphasise that as India prepares for phase 3 trials of quadrivalent dengue vaccines, understanding region-specific circulating dengue virus serotypes is crucial.

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Southern India, in particular, reports the highest dengue seroprevalence, estimated at 77 percent.

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