Biomarkers in early pregnancy offer hope for predicting gestational diabetes

Veni EN

Oct 14, 2025

Health

Health

For years, gestational diabetes has been treated as a condition that emerges midway through pregnancy. 

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But new evidence suggests that the biological signs of the disorder start showing up much earlier, even before many women realise they are at risk.

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A new scoping review has found that subtle metabolic and inflammatory changes appear in the first trimester of pregnancy, long before gestational diabetes is typically diagnosed.

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The researchers identified over 140 biomarkers linked to future risk, including lower levels of PAPP-A and higher levels of cholesterol, fasting glucose, and inflammatory markers such as CRP.

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The findings strengthen the case for early screening and intervention, offering hope that gestational diabetes could one day be predicted and prevented before it ever takes hold.